欢迎访问睡眠脑动力学研究室 　 　

宮本　大祐

众所周知大脑与人工智能不同，无法24小时保持清醒状态，需要睡眠与休息。然而睡眠中的大脑处于被外界（天敌等）信息隔离的状态，因此睡眠对于动物来说是具有风险的行为。此外，从做梦现象可以看出，睡眠中大脑的神经细胞仍处于活跃状态，并持续消耗着能量。然而关于上述风险认知和能量消耗，睡眠起到了怎样的作用至今未被知晓。睡眠中大脑为何仍维持着信息联络？睡眠对记忆，情感波动，创造力等高级脑功能起到什么作用？控制睡眠是否可对精神疾病及健康寿命的延长有所帮助？能否将睡眠时的脑网络动态运用在AI开发上？作为睡眠脑动力学研究室的目标，我们将通过电生理学、光遗传学、行为药理学等实验技巧的使用与开发，以及脑网络动态分析与模拟测试来探讨睡眠时大脑的潜能。



2020年8月　宮本大祐

 

论文发表

  1. Miyamoto D, Marshall W, Tononi G, Cirelli C (2021)
    "Net decrease in spine-surface GluA1-containing AMPA receptors after post-learning sleep in the adult mouse cortex."
    Nature Communications12(1): 2881
  2. *Miyamoto D, Hirai D, *Murayama M (2017)
    "The roles of cortical slow waves in synaptic plasticity and memory consolidation."
    Frontiers in Neural Circuits11: 92
    * Corresponding author
  3. Miyamoto D, Hirai D, Fung CCA, Inutsuka A, Odagawa M, Boehringer R, Adaikkan C, Matsubara C, Matsuki N, Fukai T, McHugh TJ, Yamanaka A, Murayama M (2016)
    "Top-Down Cortical Input during NREM Sleep Consolidates Perceptual Memory."
    Science(New York, NY). 352(6291):1315-8., 1315-8
    "First Release" in Science
  4. Miyamoto D, Murayama M (2016)
    "The fiber-optic imaging and manipulation of neural activity during animal behavior."
    Neuroscience Research103: 1-9
    "Cover article" in Neuroscience Research.
  5. Koyama R, Tao K, Sasaki T, Ichikawa J, Miyamoto D, Muramatsu R, Matsuki N, Ikegaya Y (2012)
    "GABAergic excitation after febrile seizures induces ectopic granule cells and adult epilepsy."
    Nature Medicine18(8): 1271-8
    Recommended in F1000 Prime, "News & Views" in Nature Medicine.
  6. Shen H, Fuchino Y, Miyamoto D, Nomura H, Matsuki N (2012)
    "Vagus nerve stimulation enhances perforant path-CA3 synaptic transmission via the activation of beta-adrenergic receptors and the locus coeruleus."
    International Journal of Neuropsychopharmacology15(4): 523-30

  7. Miyamoto D, Iijima M, Yamamoto H, Nomura H, Matsuki N (2011)
    "Behavioral effects of antidepressants are dependent and independent on the integrity of the dentate gyrus."
    International Journal of Neuropsychopharmacology14(7): 967-76
    Recommended in F1000 Prime