Welcome to Laboratory for Sleeping-Brain Dynamics 　　 　

Daisuke Miyamoto

　Unlike AI, the brain cannot operate at full capacity 24 hours a day and requires sleep and rest. However, sleep is a risky behavior for animals because the sleeping-brain is isolated from external inputs such as enemy information. On the other hand, as you can see from dreaming, brain neurons are active even during sleep, while consuming energy. However, it is still unclear what roles sleep plays in risk and energy. Why does the brain network communicate information even during sleep? What roles does sleep play in higher brain functions such as memory, emotions and creativity? Can sleep be controlled to help treat mental illness and extend healthy life expectancy? Is it beneficial to use the network dynamics during sleep to lead to AI development? To answer such questions, we will explore the functions of the sleeping-brain through the application and development of experimental techniques such as electrophysiology, optogenetics, and behavioral pharmacology, as well as analysis and simulations of brain network dynamics.

August 2020　Daisuke Miyamoto

 

Publication

  1. Miyamoto D, Marshall W, Tononi G, Cirelli C (2021)
    "Net decrease in spine-surface GluA1-containing AMPA receptors after post-learning sleep in the adult mouse cortex."
    Nature Communications12(1): 2881
  2. *Miyamoto D, Hirai D, *Murayama M (2017)
    "The roles of cortical slow waves in synaptic plasticity and memory consolidation."
    Frontiers in Neural Circuits11: 92
    * Corresponding author
  3. Miyamoto D, Hirai D, Fung CCA, Inutsuka A, Odagawa M, Boehringer R, Adaikkan C, Matsubara C, Matsuki N, Fukai T, McHugh TJ, Yamanaka A, Murayama M (2016)
    "Top-Down Cortical Input during NREM Sleep Consolidates Perceptual Memory."
    Science(New York, NY). 352(6291):1315-8., 1315-8
    "First Release" in Science
  4. Miyamoto D, Murayama M (2016)
    "The fiber-optic imaging and manipulation of neural activity during animal behavior."
    Neuroscience Research103: 1-9
    "Cover article" in Neuroscience Research.
  5. Koyama R, Tao K, Sasaki T, Ichikawa J, Miyamoto D, Muramatsu R, Matsuki N, Ikegaya Y (2012)
    "GABAergic excitation after febrile seizures induces ectopic granule cells and adult epilepsy."
    Nature Medicine18(8): 1271-8
    Recommended in F1000 Prime, "News & Views" in Nature Medicine.
  6. Shen H, Fuchino Y, Miyamoto D, Nomura H, Matsuki N (2012)
    "Vagus nerve stimulation enhances perforant path-CA3 synaptic transmission via the activation of beta-adrenergic receptors and the locus coeruleus."
    International Journal of Neuropsychopharmacology15(4): 523-30

  7. Miyamoto D, Iijima M, Yamamoto H, Nomura H, Matsuki N (2011)
    "Behavioral effects of antidepressants are dependent and independent on the integrity of the dentate gyrus."
    International Journal of Neuropsychopharmacology14(7): 967-76
    Recommended in F1000 Prime